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KMID : 1144820180240040411
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대한의생명과학회지
2018 Volume.24 No. 4 p.411 ~ p.417
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Effect of Extreme Long-Distance Running on Hepatic Metabolism and Renal Function in Middle-Aged Men
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Shin Kyung-Ah
Kim Young-Joo
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Abstract
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The aim of this study was to investigate the impact of participation in the 622 km hyper-ultra-marathon on hepatic metabolism and renal function in middle-aged men. Healthy middle-aged male amateur ultra-marathoners between the ages of 40 and 60. Blood was collected at the pre-race, immediately after 300 km, 622 km hyper-ultra marathon race, 72 hours (3 day) and 144 hours (6 day) after the race, AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), γ-GTP (gamma glutamyl transferase), T-Bil (total bilirubin), D-Bil (direct bilirubin), T-protein (total protein), albumin, uric acid, BUN (blood urea nitrogen), creatinne were analyzed. ALP was significantly increased at 300 km, 622 km, day 3 and day 6 than the pre-race. γ-GTP, T-protein, albumin, uric acid, BUN and creatinine were not significantly different between the distances and the recovery period respectively. AST and ALT were significantly increased at 300 km, 622 km, day 3 and day 6 than the pre-race, respectively (P＜0.05) at day 3 and day 6 they showed significant decrease from 300 km and 622 km, respectively (P＜0.05). T-Bil and D-Bil increased significantly at 300 km and 622 km, respectively (P＜.05) and significantly decreased at day 3 (P＜0.05) compared to the pre-race, at day 3 and day 6 they were decreased significantly than 300 km and 622 km, respectively (P＜0.05). In conclusion, no disturbance of renal function was observed according to the distances and between the recovery period of 622 km hyper-ultra marathon race, but reversible hepatocyte function could be degraded and some hemolysis of blood vessels was induced.
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KEYWORD
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Ultra-marathon, Hepatic metabolism, Renal function
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